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BM0019

BMS-777607

≥98% (HPLC)

Synonym(s):

BMS-817378, N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C25H19ClF2N4O4
CAS Number:
1025720-94-8
Molecular Weight:
512.89
NACRES:
NA.77
PubChem Substance ID:
329774362
UNSPSC Code:
12352200
MDL number:
MFCD16495773
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

room temp

SMILES string

ClC1=C(N)N=CC=C1OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F

InChI

1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)

InChI key

VNBRGSXVFBYQNN-UHFFFAOYSA-N

Gene Information

human ... MET(4233)

Biochem/physiol Actions

RON kinase inhibitor (RONi, BMS-777607) decreases recepteur d′origine nantais (RON) signaling. This Met kinase inhibitor represses prostate cancer metastatic phenotype in vitro, induced by hepatocyte growth factor.
BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively, for Ron, Met, Tyro-3, and AxI kinases. BMS-777607 has been studied in a variety of cancer models and has shown anti-cancer activity, causing increased apoptosis, and decreased proliferation and migration, although it has also been shown to induce polyploidy, which may lead to chemoresistance.
BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily.

Features and Benefits

BMS-777607 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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