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Merck
CN

BM0021

BMY-14802

≥97% (HPLC)

Synonym(s):

α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol, (±)-BMY 14802, BMS 181100, BMY-014802, BMY14802

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About This Item

Empirical Formula (Hill Notation):
C18H22F2N4O
CAS Number:
105565-56-8
Molecular Weight:
348.39
UNSPSC Code:
12352200
PubChem Substance ID:
329774364
MDL number:
MFCD00899512

Key Documents

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InChI

1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2

SMILES string

FC1=CC=C(C(O)CCCN2CCN(C3=NC=C(F)C=N3)CC2)C=C1

InChI key

ZXUYYZPJUGQHLQ-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

Biochem/physiol Actions

BMY-14802 is a potent and selective sigma-1 (σ1) receptor antagonist with an IC50 value of approximately 100 nM. BMY-14802 shows low affinity at serotonin (5-HT) 1A and adrenergic σ1 receptors and minimal activity at dopamine receptors. BMY-14802 has exhibited antipsychotic activity in rodent models and anti-dyskinetic effects against L-DOPA with preservation of antiparkinsonian efficacy.
BMY-14802 is a potent and selective sigma-1 (σ1) receptor antagonist.

Features and Benefits

BMY-14802 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086M4732V

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