Skip to Content
Merck
CN

Key Documents

View All Documentation

BX-0900-32

Human Microglia

Human iPSC line, Fully differentiated, Healthy Female Control (no known neurological disorders), Cryopreserved

Synonym(s):

Brain macrophages

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Biological source:
human (iPSC line)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

human (iPSC line)

form

frozen liquid

packaging

vial of 1 (contains ≥1 million cells)

technique(s)

cell culture | mammalian: suitable

shipped in

liquid nitrogen

storage temp.

-140 to -196°C

General description

Human iPSC-Derived Microglia. Cells derived from male (BX-0900-30-1M) and female (BX-0900-32-1M) lines available. GFP-expressing neurons also available (BX-0901-30-1M). A major immune cell within the central nervous system (CNS), microglia are responsible for eliminating dead neurons, microbes, protein aggregates, and other particulates like degenerating synapses and myelin debris that are in the CNS. They also help to maintain neuronal networks, aid in injury repair, and mediate neuroinflammation. Microglia are implicated in neurodegeneration and aging, and are used to study autism, epilepsy, Alzheimer’s disease, and Huntington’s disease.

Application

Function: Human Microglia demonstrate phagocytosis and can be stimulated to secrete a variety of cytokines.

Features and Benefits

Marker Expression: Fully differentiated with confirmed expression of microglia surface markers including: CD45, CD11b, CX3CR1, P2RY12, and TMEM119. Immunocytochemistry shortly after plating microglia (shown here with a DAPI stain) reveals prominent expression of TREM2 (green) and IBA1 (red).

Still not finding the right product?

Explore all of our products under Human Microglia

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protocols

Protocol Guide: Neuron and Microglia Co-Culture Assay

Discover an expert protocol for seeding and co-culturing iPSC-derived neurons and microglia in monoculture. Explore high purity cells and culture reagents.

Protocol Guide: Motor Neuron Monoculture

Discover an expert protocol for seeding and culturing motor neurons in monoculture. Explore high purity motor neurons culture cells and reagents.

Protocol Guide: Microglia Monoculture

Discover an expert protocol for seeding and culturing microglia in monoculture. Explore high purity microglia and cell culture reagents.

View All Protocols

Articles

Protocol Guide: Functional Tri-Culture of iPSC-Derived Human Neurons, Astrocytes, and Microglia

Discover an expert protocol for seeding and tri-culturing iPSC-derived neurons, astrocytes, and microglia in monoculture. Explore high purity cells and culture reagents.

Protocol Guide: Cortical GABAergic Neuron Monoculture

Discover an expert protocol for seeding and culturing cortical GABAergic neurons in monoculture. Explore GABAergic neuron culture cells and reagents.

Rezwanul Islam et al.
Translational stroke research, 16(3), 655-671 (2024-04-01)
Subarachnoid hemorrhage (SAH) accounts for 5% of stroke, with women having a decreased inflammatory response compared to men; however, this mechanism has yet to be identified. One hurdle in SAH research is the lack of human brain models. Studies in