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C0399

Cromolyn sodium salt

Name: Cromolyn sodium salt
Brand: SIGMA

≥95%, Mast cell stabilizer, powder

Synonym(s):

Cromoglycate, Cromoglycic acid

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About This Item

Linear Formula:

C₂₃H₁₄O₁₁Na₂

CAS Number:

15826-37-6

Molecular Weight:

512.33

NACRES:

NA.77

PubChem Substance ID:

24892251

UNSPSC Code:

12352200

EC Number:

239-926-7

MDL number:

MFCD00057744

Assay:

≥95%

Form:

powder

Quality level:

200

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Product Name

Cromolyn sodium salt, ≥95%

Quality Level

200

assay

≥95%

form

powder

originator

Sanofi Aventis

SMILES string

[Na].OC(COc1cccc2OC(=CC(=O)c12)C(O)=O)COc3cccc4OC(=CC(=O)c34)C(O)=O

InChI

1S/C23H16O11.Na.H/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;

InChI key

UXMUBZWVLQEMRB-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

General description

Cromolyn sodium is a mast stabilizer, which is used to treat allergies. It is a bischromone and functions as a non-steroidal anti-inflammatory drug. It inhibits the release of histamines from mast cells.

Application

Cromolyn sodium salt has been used to block mast cell activation and to inhibit histamine secretion from rodent peritoneal mast cells. It has also been used to stabilize mast cells.

Biochem/physiol Actions

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.

Zuyi Weng et al.

PloS one, 7(3), e33805-e33805 (2012-04-04)

Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such

Neuropeptide Initiated Mast Cell Activation by Transcutaneous Electrical Acupoint Stimulation of Acupoint LI4 in Rats

Chen LZ, et al.

Scientific Reports, 8(1), 13921-13921 (2018)

Mast cells and histamine are triggering the NF-kappaB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation

Nizamutdinova IT, et al.

Aging (Albany. NY.), 8(11), 3065-3065 (2016)

Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats.

Pinjie Huang et al.

Injury, 43(8), 1250-1256 (2012-01-27)

Small intestinal ischemia-reperfusion (IIR) injury may lead to severe local and remote tissue injury, especially acute lung injury (ALI). Mast cell activation plays an important role in IIR injury. It is unknown whether IIR mediates lung injury via mast cell

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

Shaun A Summers et al.

Kidney international, 82(6), 676-685 (2012-06-08)

Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that

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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Global Trade Item Number

SKU	GTIN
C0399-25G	04061832631813
C0399-5G	04061833450536
C0399-1G	04061833450529

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