C0483
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
≥95%, solid
Synonym(s):
Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC
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About This Item
Empirical Formula (Hill Notation):
C35H44N4O9
Molecular Weight:
664.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥95%
Form:
solid
Quality Segment
assay
≥95%
form
solid
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
InChI key
FOYHOBVZPWIGJM-KCHLEUMXSA-N
General description
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.
Application
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.
Biochem/physiol Actions
Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
Fluorogenic substrate to measure peptidylglutamyl-peptide hydrolyzing activity of 20S proteasome.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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