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Merck
CN

C0742

CKI-7 dihydrochloride

≥98% (HPLC), solid, CK1 inhibitor

Synonym(s):

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H12ClN3O2S · 2HCl
CAS Number:
1177141-67-1
Molecular Weight:
358.67
UNSPSC Code:
12352200
PubChem Substance ID:
24724430
NACRES:
NA.77
MDL number:
MFCD00897689

Key Documents

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Product Name

CKI-7 dihydrochloride, ≥98% (HPLC), solid

SMILES string

Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12

InChI key

JUAVTXYOCISSSL-UHFFFAOYSA-N

InChI

1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to light tan

solubility

H2O: >5 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1.
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

Disclaimer

Material is hygroscopic

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000492838
0000492838
0000405882
0000385438
0000335165

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