C0742
CKI-7 dihydrochloride
≥98% (HPLC), solid, CK1 inhibitor
Synonym(s):
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C11H12ClN3O2S · 2HCl
CAS Number:
Molecular Weight:
358.67
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
Product Name
CKI-7 dihydrochloride, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to light tan
solubility
H2O: >5 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
InChI
1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
InChI key
JUAVTXYOCISSSL-UHFFFAOYSA-N
Biochem/physiol Actions
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1.
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.
Disclaimer
Material is hygroscopic
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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