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Merck
CN

C0980

Z-Gly-Pro-Arg 7-amido-4-trifluoromethylcoumarin trifluoroacetate salt

≥95% (HPLC), powder

Synonym(s):

Z-GPR-AFC trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C33H35F6N7O9
Molecular Weight:
787.66
NACRES:
NA.32
PubChem Substance ID:
329774830
UNSPSC Code:
12352209
MDL number:
MFCD03452879

Key Documents

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Product Name

Z-Gly-Pro-Arg 7-amido-4-trifluoromethylcoumarin trifluoroacetate salt, ≥95% (HPLC), powder

InChI

1S/C31H34F3N7O7/c32-31(33,34)21-15-26(43)48-24-14-19(10-11-20(21)24)39-27(44)22(8-4-12-37-29(35)36)40-28(45)23-9-5-13-41(23)25(42)16-38-30(46)47-17-18-6-2-1-3-7-18/h1-3,6-7,10-11,14-15,22-23H,4-5,8-9,12-13,16-17H2,(H,38,46)(H,39,44)(H,40,45)(H4,35,36,37)/t22-,23-/m0/s1

SMILES string

NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc2ccccc2)C(=O)Nc3ccc4c(OC(=O)C=C4C(F)(F)F)c3

InChI key

YNFWCRXESGJYDC-GOTSBHOMSA-N

assay

≥95% (HPLC)

form

powder

color

white to off-white

solubility

DMSO or DMF: 20 mM

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GZMA(3001)
mouse ... GZMA(14938)
rat ... GZMA(266708)

Application

Fluorogenic substrate for granzyme A.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0000430188
0000430188
0000427647
0000427647
SLCR1692

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F Velotti et al.
European journal of immunology, 22(4), 1049-1053 (1992-04-01)
Granzymes A-G are a family of serine proteases localized in the cytoplasmic granules of cytotoxic T lymphocytes (Masson, D. et al. Cell 1987. 49: 679) and granzyme A is secreted by T lymphocytes in response to antigenic stimulation. Granzyme A
M J Smyth et al.
The Journal of biological chemistry, 267(34), 24418-24425 (1992-12-05)
We have purified a 30-kDa serine protease (designated RNK-Met-1) from the granules of the rat large granular lymphocyte leukemia cell line (RNK-16) that hydrolytically cleaves model peptide substrates after methionine, leucine, and norleucine (Met-ase activity). Utilizing molecular sieve chromatography, heparin-agarose

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