C0984
Creatine Kinase MB Fraction from human heart
≥70% (SDS-PAGE), liquid
Synonym(s):
CK MB Fraction
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About This Item
Assay:
≥70% (SDS-PAGE)
Biological source:
human heart
Concentration:
≥0.5 mg/mL
General description
Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Application
Creatine Kinase MB Fraction from human heart has been used:
- as a diagnostic marker for acute myocardial infarction.
- to identify overlapping absorbance peaks between blood and the cardiac biomarkers.
- to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.
Biochem/physiol Actions
Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels. CK-MB levels may also be elevated in chronic renal failure.
Other Notes
Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
Titus J, et al.
Communications medicine, 2 (2022)
J E Adams et al.
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C0984-100UG | 04061838070418 |