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C113000

DMT-dC(ac) Phosphoramidite

Name: DMT-dC(ac) Phosphoramidite
Brand: SIGMA

≥99.0% (reversed phase HPLC)

Synonym(s):

DMT-dC(ac) Amidite, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N4-Acetyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₅₀N₅O₈P

CAS Number:

154110-40-4

Molecular Weight:

771.84

NACRES:

NA.51

PubChem Substance ID:

329774860

UNSPSC Code:

12352200

MDL number:

MFCD09842112

Assay:

≥98% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

Biological source:

non-animal source (no BSE/TSE risk)

Form:

powder

Solubility:

water: insoluble

Storage temp.:

-10 to -25°C

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Properties

biological source

non-animal source (no BSE/TSE risk)

Quality Level

200

type

for DNA synthesis

product line

Proligo Reagents

assay

≥98% (³¹P-NMR), ≥99.0% (reversed phase HPLC)

form

powder

mol wt

771.85 g/mol

packaging

pkg of 6 × 10 g C113000-6x10G (16 oz Bottle)

technique(s)

oligo synthesis: suitable

color

white to off-white

solubility

water: insoluble

λ

conforms (UV/VIS Identity)

nucleoside profile

base: deoxycytidine
base protecting group: acetyl
2' protecting group: none
5' protecting group: DMT
deprotection: fast/standard

storage temp.

-10 to -25°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C41H50N5O8P/c1-28(2)46(29(3)4)55(52-25-11-23-42)54-36-26-39(45-24-22-38(43-30(5)47)44-40(45)48)53-37(36)27-51-41(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,28-29,36-37,39H,11,25-27H2,1-7H3,(H,43,44,47,48)/t36-,37+,39+,55?/m0/s1

InChI key

MECWEBCHRKVTNV-RLWDVSNXSA-N

Description

General description

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. DMT-dC(ac) Phosphoramidite is an acetyl-protected DNA phosphoramidite used in fast deprotection chemistry for the rapid and high-yield synthesis of high-purity oligonucleotides. The product belongs to MerMade synthesizers.

Features and Benefits

Key Features of dC(ac):

Ultrafast deprotection: 10 minutes at 65°C with AMA reagent
Key component in oligonucleotide synthesis
Industry standard for fast deprotection chemistry
Operating for AMA deprotection methods without changes
Consistent lot-to-lot high purity and performance
Manufactured under a certified ISO 9001 quality system

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Global Trade Item Number

SKU	GTIN
C113000-AGL	04061826590430
C113000-6X10G	04061833650509
C113000-100G	04061833412688
C113000-6X5G	04061833368756
C11300S-C	04061841368830
C113000-1KG	04061833444702
C113000-6X20G	04061833401736
C113000-GIR	04061826590447
C113000-500G	04061832025346
C11300S-1KG	04061841368823
C113000-BIO	04061822540880
C113000-C	04061826703038