C1145
Cholesterol–PEG 600
Synonym(s):
Cholesterol, water soluble from sheep, Cholesteryl-polyethylene glycol 600 sebacate, Polyethylene glycol 600 mono(cholesteryl) ether sebacate, Polyoxyethyl-cholesteryl sebacate
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About This Item
Form:
solid
Quality level:
form
solid
extent of labeling
≥20% cholesterol
color
light yellow
solubility
H2O: 60 mg/mL
shipped in
dry ice
storage temp.
−20°C
Quality Level
Application
Cholesterol-PEG 600 has been used to evaluate its ability to induce apoptosis in vascular smooth muscle cells. It has also been used to restore cholesterol following depletion by methyl β-cyclodextrin.
Biochem/physiol Actions
Cholesterol acts as an antecedent of steroid hormones. It plays a key role in fetal growth and in brain development.
General description
Cholesterol is one of the important constituent of all membranes. It is made up of a hydrophobic, planar, a polar hydroxyl group, fused-ring nucleus and a short hydrocarbon tail.
Physical form
semisolid to solid
Preparation Note
Prepared by method of Proksch, G.J., and Bonderman, D.P., Clin. Chem., 24, 1924 (1978).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Linda Shaw et al.
Cardiovascular research, 69(4), 825-835 (2006-02-09)
A close association of caveolae and sarcoplasmic reticulum (SR) has been suggested to be important for contractile activation of smooth muscle. Here, we investigate the presence of such arrangements in pressurised resistance arteries and examine the influence of two agents
Disruption of cholesterol homeostasis in developmental neurotoxicity
Reproductive and Developmental Toxicology null
Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin-rich domains
Absi M, et al.
British Journal of Pharmacology, 332-340, 332-340 null
Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo
Yin J, et al.
Atherosclerosis, 148(2), 365-374 (2000)
M Absi et al.
British journal of pharmacology, 151(3), 332-340 (2007-04-24)
The small and intermediate conductance, Ca2+-sensitive K+ channels (SK(Ca) and IK(Ca), respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated. The effect of
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