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C117

5-Carboxamidotryptamine maleate salt

Name: 5-Carboxamidotryptamine maleate salt
Brand: SIGMA

powder, ≥98% (HPLC)

Synonym(s):

5-CT, AH-21467

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₃N₃O · C₄H₄O₄

CAS Number:

74885-72-6

Molecular Weight:

319.31

NACRES:

NA.77

PubChem Substance ID:

24278086

UNSPSC Code:

12352116

MDL number:

MFCD00069224

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H₂O: 10 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)\C=C/C(O)=O.NCCc1c[nH]c2ccc(cc12)C(N)=O

InChI

1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

PZQZSWAOVAMBQM-BTJKTKAUSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR2A(3356), HTR2C(3358), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
rat ... Htr7(65032)

Biochem/physiol Actions

Agonist at 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT₅ and 5-HT₇ serotonin receptors.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Pharmacodynamic, pharmacokinetic and humoral effects of oral zabicipril, an angiotensin converting enzyme inhibitor in normotensive man.

N J MacDonald et al.

British journal of clinical pharmacology, 30(1), 107-113 (1990-07-01)

1. Zabicipril, S9650, a new angiotensin converting enzyme inhibitor, was administered to salt-replete, normotensive males in single doses of up to 10 mg. 2. The safety, tolerance and dose-response relationship with regard to inhibition of plasma ACE activity were characterised

Serotonin 5-HT7 receptor is critically involved in acute and chronic inflammation of the gastrointestinal tract.

Daria Guseva et al.

Inflammatory bowel diseases, 20(9), 1516-1529 (2014-07-30)

Intestinal inflammation is often associated with an increased level of serotonin (5-HT), an important gastrointestinal signaling molecule involved in gut homeostasis through stimulation of specific receptors. In this study, we investigated the role of 5-HT7 receptor (5-HT7R) in the induction

Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.

Hao Zhang et al.

International immunopharmacology, 52, 93-100 (2017-09-11)

Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD

Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists. Part 2.

Ayako Moritomo et al.

Bioorganic & medicinal chemistry, 22(15), 4323-4337 (2014-06-12)

We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.

Kirsten E Hoff et al.

PloS one, 13(8), e0203198-e0203198 (2018-08-30)

Mutations in mitochondrial DNA (mtDNA) have been linked to a variety of metabolic, neurological and muscular diseases which can present at any time throughout life. MtDNA is replicated by DNA polymerase gamma (Pol γ), twinkle helicase and mitochondrial single-stranded binding

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Global Trade Item Number

SKU	GTIN
C117-25MG	04061832081342
C117-5MG	04061832081359

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