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C1172

ML-9

Name: ML-9
Brand: SIGMA

≥99% (TLC), powder

Synonym(s):

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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About This Item

Linear Formula:

C₁₅H₁₇N₂O₂SCl · HCl

CAS Number:

105637-50-1

Molecular Weight:

361.29

NACRES:

NA.77

PubChem Substance ID:

24278297

UNSPSC Code:

12352202

MDL number:

MFCD00065525

Assay:

≥99% (TLC)

Form:

powder

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Properties

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

color

white

solubility

ethanol: 10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI key

ZNRYCIVTNLZOGI-UHFFFAOYSA-N

Gene Information

human ... SLC2A1(6513), SLC2A4(6517)

Description

Application

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

Biochem/physiol Actions

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca₂⁺ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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