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C1244

CHM-1 hydrate

Name: CHM-1 hydrate
Brand: SIGMA

≥99% (HPLC), solid

Synonym(s):

2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₀FNO₃ · xH₂O

CAS Number:

154554-41-3

Molecular Weight:

283.25 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329774746

UNSPSC Code:

12352202

MDL number:

MFCD11114577

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

desiccated

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assay

≥99% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O.Fc1ccccc1C2=CC(=O)c3cc4OCOc4cc3N2

InChI

1S/C16H10FNO3.H2O/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12;/h1-7H,8H2,(H,18,19);1H2

InChI key

KIAVGSCBJYDTIM-UHFFFAOYSA-N

Biochem/physiol Actions

CHM-1 possess antimitotic and antiangiogenic antitumor activity.

CHM-1 possess antimitotic,antiangiogenic and antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

058K4602V

058K4602

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Articles

Cyclin-dependent Kinases (CDKs)

Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).

Global Trade Item Number

SKU	GTIN
C1244-5MG	04061832923550
C1244-25MG	04061832269818

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