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C1254

Sodium cholate hydrate

Name: Sodium cholate hydrate
Brand: SIGMA

from bovine and/or ovine bile, ≥99%

Synonym(s):

3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₉NaO₅ · xH₂O

CAS Number:

206986-87-0

Molecular Weight:

430.55 (anhydrous basis)

UNSPSC Code:

12161900

NACRES:

NA.25

PubChem Substance ID:

24892390

EC Number:

206-643-5

Beilstein/REAXYS Number:

3582354

MDL number:

MFCD00150749

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Properties

biological source

bovine and/or ovine bile

Quality Segment

200

description

anionic

assay

≥99%

form

powder

mol wt

micellar avg mol wt 900-1300

aggregation number

2-3

technique(s)

DNA purification: suitable, RNA purification: suitable, western blot: suitable

CMC

9-15 mM (20-25°C)

solubility

water: 100 mg/mL, clear, colorless to light yellow

HLB

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1

InChI key

MUVVIYFKOVLQHL-RCVKHMDESA-M

Description

General description

Sodium cholate hydrate, a non-denaturing anionic detergent, plays a crucial role in biochemical research, particularly in protein solubilization and membrane permeabilization, making it essential for protein extraction and purification, especially when dealing with membrane proteins and protein complexes. Derived from cholic acid, a prevalent human bile acid, sodium cholate hydrate′s water solubility and its applications extend to investigating the effects of various substances on cell cultures, making it a versatile tool in laboratory research.

Application

Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.

Biochem/physiol Actions

Bile Salt

Features and Benefits

Suitable for Western blotting
Suitable for DNA and RNA purification
High purity product for research applications

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Hazard Codes

H412

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)