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CN

C1335

S-(−)-Carbidopa

≥98% (TLC), powder

Synonym(s):

(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O4
CAS Number:
28860-95-9
Molecular Weight:
226.23
NACRES:
NA.77
PubChem Substance ID:
24892402
UNSPSC Code:
12352202
EC Number:
249-271-9
MDL number:
MFCD00069231

Key Documents

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Product Name

S-(−)-Carbidopa, ≥98% (TLC), powder

InChI key

TZFNLOMSOLWIDK-JTQLQIEISA-N

InChI

1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1

SMILES string

CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O

assay

≥98% (TLC)

form

powder

solubility

methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

200

Gene Information

human ... DDC(1644)

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Biochem/physiol Actions

Peripheral inhibitor of L-aromatic amino acid decarboxylase.
Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H2O2 in these cell lines, which are sensitive to reactive oxygen species.

General description

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000133058
0000133058
0000397928
0000397928
0000290557

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Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients
Earley CJ and Allen RP
Sleep, 19(10), 801-810 (1996)
S Kaakkola et al.
Journal of neurochemistry, 60(1), 137-144 (1993-01-01)
The effects of two new catechol-O-methyltransferase (COMT) inhibitors, OR-611 and Ro 40-7592, in combination with L-3,4-dihydroxyphenylalanine (L-dopa) with or without carbidopa on extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-O-methyldopa (3-OMD), and 5-hydroxyindoleacetic acid in rat
D Deleu et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(6), 576-581 (1993-12-01)
The effect of carbidopa on the pharmacokinetics and metabolism of levodopa (L-dopa) in blood plasma and skeletal muscle extracellular fluid (ECF) has been studied by repeated measurements in one beagle dog. The administration of a single dose of L-dopa (25
Extended-release carbidopa-levodopa in Parkinson's disease.
Olivier Rascol
The Lancet. Neurology, 12(4), 325-326 (2013-03-15)
Jesse D Ennis et al.
American journal of physical medicine & rehabilitation, 92(4), 307-311 (2012-12-12)
The aim of this study was to evaluate the role of levodopa/carbidopa as an augmenting agent to improve motor recovery after brain tumor excision. This case report is structured as an n-of-1 style trial. The study patient was an outpatient
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