C1399
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse
clone KS-B17.2, ascites fluid
Synonym(s):
Anti-CK18
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About This Item
Conjugate:
unconjugated
Clone:
KS-B17.2, monoclonal
Application:
ARR, IF, IHC (p)
Citations:
14
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
KS-B17.2, monoclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human tissue, microarray: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
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General description
Monoclonal anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Immunogen
keratin from the bovine mammary gland epithelial cell line BMGE.
Application
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse has been used in:
- immunofluorescence
- immunoperoxidase staining
- immunocytochemistry
- microarray
Biochem/physiol Actions
Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.
The antibody reacts with a wide variety of simple epithelia (gastrointestinal, respiratory, urinary, liver, and glandular) but does not react with most stratified squamous epithelium (esophagus, epidermis) or non-epithelial cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
动物来源生物产品
常规特殊物品
常规特殊物品
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S K Mohapatra et al.
Animal : an international journal of animal bioscience, 9(4), 643-649 (2014-12-11)
Insulin-like growth factor binding protein-5 (IGFBP-5) is a key molecule in mammary gland development, which facilitates the removal of mammary epithelial cells (MECs) by apoptosis that takes place during remodeling of the mammary gland during involution. IGFBP-5 binds with IGFs
Trehalose maintains vitality of mouse epididymal epithelial cells and mediates gene transfer.
Qu B, et al.
PLoS ONE, 9(3), e92483-e92483 (2014)
The identification and localization of two intermediate filament proteins in the tunic of Styela plicata (Tunicata, Styelidae).
Di Bella MA, et al.
Tissue & cell, 41(6), 381-389 (2009)
R Levy et al.
Differentiation; research in biological diversity, 39(3), 185-196 (1988-12-01)
The aim of the present study was to explore the histogenesis of metaplastic cells in the human uterine cervix. In a previous study we demonstrated that squamous cervical metaplasia expresses a unique set of cytokeratin polypeptides different from that expressed
P H Chen et al.
Journal of virology, 67(6), 3507-3514 (1993-06-01)
Immunofluorescence studies revealed that adenovirus induces a reorganization of the cytokeratin system in lytically infected HeLa cells. At 24 h postinfection, the cytokeratin network began to disassemble into prominent spheroid globules. By 36 h postinfection, host cell lysis occurred, accompanied
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C1399-.2ML | 04061838162601 |
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