Skip to Content
Merck
CN

C144

1-(3-Chlorophenyl)biguanide hydrochloride

solid

Synonym(s):

1-(m-Chlorophenyl)biguanide hydrochloride, N-(3-Chlorophenyl)imidodicarbonimidic diamide hydrochloride, m-CPBG hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
CAS Number:
2113-05-5
Molecular Weight:
248.11
NACRES:
NA.77
PubChem Substance ID:
24278089
UNSPSC Code:
12352202
MDL number:
MFCD00053019
Form:
solid

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H

SMILES string

Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1

InChI key

FOWAIJYHRWFTHR-UHFFFAOYSA-N

form

solid

color

white

mp

190-194 °C (lit.)

solubility

H2O: soluble

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Very potent 5-HT3 serotonin receptor agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLCD2737
SLCB1913
SLBS8107
SLBN9992V
SLBF8520V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Zachary A Rodd et al.
The Journal of pharmacology and experimental therapeutics, 321(3), 1003-1012 (2007-02-28)
Studies from our laboratory indicated that local perfusion of the ventral tegmental area (VTA) with a serotonin-3 (5-HT(3)) receptor agonist increased dopamine (DA) neuronal activity and that the self-infusion of ethanol (EtOH) and cocaine into the posterior VTA could be
Borna Payandemehr et al.
Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
G J Kilpatrick et al.
European journal of pharmacology, 182(1), 193-197 (1990-06-21)
1-(m-Chlorophenyl)-biguanide (mCPBG) was examined and compared with three 5-HT3 receptor agonists in three 5-HT3 receptor models. mCPBG inhibited [3H]GR67330 binding to 5-HT3 receptors with high affinity (IC50 1.5 nM). mCPBG depolarized the rat vagus nerve with an EC50 one tenth
Jaime M Monti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(4), 940-947 (2008-02-26)
The effects of the selective 5-HT(3) receptor agonist and antagonist m-chlorophenylbiguanide (m-CPBG) and ondansetron, respectively, were studied in adult male Wistar rats implanted for chronic sleep recordings. Microinjection of m-CPBG (2.0 and 4.0 mM) into the dorsal raphe nucleus (DRN)
Philip M Lang et al.
Journal of neurophysiology, 96(6), 2963-2971 (2006-09-08)
Activity-dependent fluctuations in axonal excitability and changes in interspike intervals modify the conduction of trains of action potentials in unmyelinated peripheral nerve fibers. During inflammation of a nerve trunk, long stretches of axons are exposed to inflammatory mediators such as
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service