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C1493

Cilnidipine

Name: Cilnidipine
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester, FRC 8653

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₈N₂O₇

CAS Number:

132203-70-4

Molecular Weight:

492.52

NACRES:

NA.77

PubChem Substance ID:

24892414

UNSPSC Code:

12352200

MDL number:

MFCD00865853

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

light yellow

solubility

H₂O: ≤2 mg/mL, DMSO: ≥20 mg/mL

SMILES string

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC\C=C\c3ccccc3

InChI

1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChI key

KJEBULYHNRNJTE-DHZHZOJOSA-N

Description

Application

Cilnidipine has been used:

in cell viability assay of pheochromocytoma (nPC12) cells
in photoirradiation and photodegradation studies
to understand effect on albuminuria in diabetic nephropathy

Biochem/physiol Actions

A slow-acting Ca²⁺ channel blocker, antihypertensive; vasodilator.

Cilnidipine is a slow-acting Ca²⁺ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca²⁺ channels in vascular smooth muscle and N-type Ca²⁺channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Protect from high temperatures.

pictograms

GHS05

signalword

Danger

hcodes

H318

pcodes

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Articles

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Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products.

Sayaka Masada et al.

Scientific reports, 9(1), 11852-11852 (2019-08-16)

In July 2018, certain valsartan-containing drugs were voluntary recalled in Japan owing to contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. In this study, an HPLC method was developed for the quantitative detection of NDMA simultaneously eluted with valsartan. Good

Photoinduced Aromatization of Asymmetrically Substituted 1, 4-Dihydropyridine Derivative Drug Cilnidipine

Ahmad W

Journal of Photochemistry, 2014(1), 90-100 (2014)

Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial.

Hiroaki Matsuoka et al.

Clinical and experimental hypertension (New York, N.Y. : 1993), 33(7), 455-462 (2011-06-09)

Recently, it has been demonstrated that L-/N-type calcium channel blockers (CCBs), cilnidipine, but not L-type CCB, decreased urinary protein in renin-angiotensin system (RAS), inhibitor-treated hypertensive patients with macroproteinuria. However, the antiproteinuric effect of cilnidipine was weaker in diabetic patients than

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Global Trade Item Number

SKU	GTIN
C1493-50MG	04061832961477
C1493-10MG	04061832961460