C1538
Complement C8 deficient serum human
for complement assays
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
NACRES:
NA.61
UNSPSC Code:
12352202
Biological source:
human
Origin:
USA origin
Form:
solution
Shipped in:
dry ice
Product Name
Complement C8 deficient serum human, for complement assays
biological source
human
form
solution
origin
USA origin
technique(s)
activity assay: suitable
impurities
infectious agent, tested
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... C8A(731)
Analysis Note
C8 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.
Application
Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.
Biochem/physiol Actions
Serum naturally deficient in C8 may actually contain some C8, though in greatly reduced quantity. Terminal complement complex is present at trace levels in such sera.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Physical form
Supplied as a solution in PBS, pH 7.3
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
T E Mollnes et al.
Scandinavian journal of immunology, 24(3), 307-312 (1986-09-01)
The terminal complement complex (TCC) was quantified in sera from patients with a genetic deficiency of C8 alpha-gamma or C8 beta. The individual sera contained only trace amounts of TCC compared with a normal serum pool. The content of TCC
L Saucedo et al.
Journal of immunology (Baltimore, Md. : 1950), 155(10), 5022-5028 (1995-11-15)
We studied the molecular bases for C8 beta deficiency in 34 unrelated families from the United States and the former Soviet Union. These families represented 69 unrelated null alleles of which 59 (86%) were found to be due to a
W P Kolb et al.
Journal of immunology (Baltimore, Md. : 1950), 122(5), 2103-2111 (1979-05-01)
C1q, a subcomponent of the first component of complement, has been isolated from human serum in fully hemolytically active form by affinity column chromatography and gel filtration with Bio-Gel A-5M. The affinity column was prepared by covalent coupling of purified
Related Content
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service