Monoclonal Anti-Polycystin-1 antibody produced in mouse

Monoclonal Anti-Polycystin-1 (mouse IgM isotype) is derived from the hybridoma PKD46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human polycystin-1, conjugated to KLH. Polycystin-1 is composed of a large N-terminal extracellular region that contains several ligand-binding domains, multiple transmembrane domains and a cytoplasmic C-tail. It has a wide tissue distribution, with higher expression in the kidney, brain, liver, pancreas, heart and intestine.

Polycystin-1 is a protein encoded by the PKD1 gene in humans. It is also referred as PBP, Pc-1 and TRPP1. Polycystic kidney disease 1 (PKD1) gene is found on chromosome 16. It is a glycoprotein with multiple transmembrane domains and a cytoplasmic C-tail.

synthetic peptide corresponding to amino acids 4282-4300 of human polycystin-1, conjugated to KLH.

Monoclonal Anti-Polycystin-1 antibody produced in mouse has been used in immunoblotting and immunohistochemistry.

PKD1 protein is involved in the adhesion of protein-protein and protein-carbohydrate interactions in the extracellular compartment. The most common cause of autosomal dominant polycystic kidney disease (ADPKD) is due to mutation in the PKD1 gene. Alterations in single base substitutions within the coding sequence lead to missense or synonymous mutations in PKD1 gene. ADPKD caused by mutations in PKD1 gene is more severe than that caused by PKD2 gene mutations.

Polycystin-1 is associated with renal tubulogenesis and intracellular signaling pathways.

Solution containing 15 mM sodium azide.

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