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C213050

DMT-2′O-TBDMS-rC(ac) Phosphoramidite

configured for (ÄKTA® and OligoPilot®)

Synonym(s):

N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-cytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

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About This Item

Empirical Formula (Hill Notation):
C47H64N5O9PSi
CAS Number:
121058-88-6
Molecular Weight:
902.10
NACRES:
NA.51
PubChem Substance ID:
329774951
UNSPSC Code:
12352200
MDL number:
MFCD09842111
Assay:
≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)
Biological source:
non-animal source (no BSE/TSE risk)
Form:
powder
Storage temp.:
−20°C
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biological source

non-animal source (no BSE/TSE risk)

Quality Segment

300

product line

Proligo Reagents

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

form

powder

technique(s)

oligo synthesis: suitable

impurities

≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content

color

white to off-white

λ

conforms (UV/VIS Identity)

suitability

conforms to structure for H-NMR, conforms to structure for LC-MS

compatibility

configured for (ÄKTA® and OligoPilot®)

nucleoside profile

base: cytidine
base protecting group: acetyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: fast/standard

storage temp.

−20°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1

InChI key

QKWKXYVKGFKODW-YOEDQOPESA-N

General description

DMT-2′O-TBDMS-rC(ac) Phosphoramidite belongs to the 2′O-TBDMS RNA Phosphoramidites.

Features and Benefits

  • Industry standard 2′O-TBDMS protective group
  • Consistent lot-to-lot purity and performance
  • Compatible with deprotection methods based on methylamine or AMA
  • Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with Activator 42
  • Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
  • Manufactured under a certified ISO 9001 quality system

Legal Information

OligoPilot is a registered trademark of Cytiva
ÄKTA is a registered trademark of Cytiva

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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