C223
Cirazoline hydrochloride
solid
Synonym(s):
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C13H16N2O · HCl
CAS Number:
Molecular Weight:
252.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
254-995-3
MDL number:
Form:
solid
form
solid
Quality Segment
color
white
solubility
H2O: >35 mg/mL
SMILES string
Cl[H].C1CN=C(COc2ccccc2C3CC3)N1
InChI
1S/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13;/h1-4,10H,5-9H2,(H,14,15);1H
InChI key
XFRXWLWUUDJHPB-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Application
Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.
Biochem/physiol Actions
Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.
Features and Benefits
This compound is featured on the α1-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Articles
Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C223-10MG | 04061832089690 |