C2230
Coelenterazine, native
solid
Synonym(s):
3,2-Dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one, CLZN
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About This Item
Empirical Formula (Hill Notation):
C26H21N3O3
CAS Number:
Molecular Weight:
423.46
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥95% (TLC)
form
solid
solubility
methanol and ethanol: soluble
storage temp.
−20°C
SMILES string
Oc1ccc(CC2=NC3=C(Cc4ccccc4)NC(=CN3C2=O)c5ccc(O)cc5)cc1
InChI
1S/C26H21N3O3/c30-20-10-6-18(7-11-20)15-23-26(32)29-16-24(19-8-12-21(31)13-9-19)27-22(25(29)28-23)14-17-4-2-1-3-5-17/h1-13,16,27,30-31H,14-15H2
InChI key
YHIPILPTUVMWQT-UHFFFAOYSA-N
General description
Coelenterazine is a luciferin molecule, which is utilized by several luciferases, such as Renilla, Oplophorus and Periphylla.
Application
Coelenterazine, native was used:-
- For Aequorin assays
- For measuring the intracellular calcium concentration in response to ionomycin or PMA using aequorin in COS-7 cells
- In Bioluminescence imaging for analysing the presence of virus-dependent luciferase activity
Biochem/physiol Actions
Luminophore of the aequorin complex used to measure Ca2+ concentration.
Luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465 nm when Ca2+ binds to the complex; used to measure Ca2+ concentration in cells with high sensitivity and large dynamic range.
Disclaimer
Protect from exposure to light
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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