C2313
Compound 48/80
powder, hypotensive agent
Synonym(s):
Poly-p-methoxyphenethylmethylamine
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About This Item
UNSPSC Code:
41106300
NACRES:
NA.77
Form:
powder
General description
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Application
Compound 48/80 has been used:
- to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
- to induce mast cell degranulation
- to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice
Biochem/physiol Actions
Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.
Preparation Note
Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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