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Merck
CN

C2335

Casein Kinase I substrate

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C85H139N27O35S
CAS Number:
154444-97-0
Molecular Weight:
2131.24
NACRES:
NA.32
PubChem Substance ID:
329774994
UNSPSC Code:
12352204
MDL number:
MFCD00672412

Key Documents

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Product Name

Casein Kinase I substrate, ≥95% (HPLC)

InChI key

GPNUIDBXUOTUMT-LVTIADEOSA-N

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O

InChI

1S/C85H139N27O35S/c1-9-38(4)64(81(144)112-65(41(7)114)82(145)97-40(6)83(146)147)111-80(143)56(35-113)110-73(136)49(23-27-148-8)98-66(129)39(5)96-68(131)46(17-20-57(115)116)102-76(139)52(30-60(121)122)107-72(135)48(19-22-59(119)120)101-71(134)47(18-21-58(117)118)103-77(140)53(31-61(123)124)109-79(142)55(33-63(127)128)108-75(138)51(29-42-34-92-36-95-42)105-74(137)50(28-37(2)3)104-78(141)54(32-62(125)126)106-70(133)44(15-10-11-24-86)100-69(132)45(16-13-26-94-85(90)91)99-67(130)43(87)14-12-25-93-84(88)89/h34,36-41,43-56,64-65,113-114H,9-33,35,86-87H2,1-8H3,(H,92,95)(H,96,131)(H,97,145)(H,98,129)(H,99,130)(H,100,132)(H,101,134)(H,102,139)(H,103,140)(H,104,141)(H,105,137)(H,106,133)(H,107,135)(H,108,138)(H,109,142)(H,110,136)(H,111,143)(H,112,144)(H,115,116)(H,117,118)(H,119,120)(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H,146,147)(H4,88,89,93)(H4,90,91,94)/t38-,39-,40-,41+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,64-,65-/m0/s1

assay

≥95% (HPLC)

form

powder

potency

172 μM Km

composition

Peptide content, ~70%

UniProt accession no.

P50411

storage temp.

−20°C

Quality Level

200

Gene Information

rat ... Ppp1r2(192361)

Biochem/physiol Actions

Vmax with casein kinase-1 is 6-fold higher than for casein. Rate of phosphorylation by casein kinase-2 is negligible.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC5413
BCBD6552V
1412180
086K1795
113K1412

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Avanti Gokhale et al.
The Journal of cell biology, 186(6), 817-824 (2009-09-16)
Experimental analysis of isolated ciliary/flagellar axonemes has implicated the protein kinase casein kinase I (CK1) in regulation of dynein. To test this hypothesis, we developed a novel in vitro reconstitution approach using purified recombinant Chlamydomonas reinhardtii CK1, together with CK1-depleted
O Marin et al.
Biochemical and biophysical research communications, 198(3), 898-905 (1994-02-15)
The available information about the specificity determinants of casein kinases-1 and -2 (CK1 and CK2) has been utilized to obtain two new peptide substrates optimally suited for the specific monitoring of these two pleiotropic enzymes. The best substrate developed for

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