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C2499

Sigma-Aldrich

CP-339818

≥98% (HPLC)

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Synonym(s):
N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
Empirical Formula (Hill Notation):
C21H24N2 · HCl
CAS Number:
478341-55-8
Molecular Weight:
340.89
MDL number:
MFCD09878238
PubChem Substance ID:
329775008
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

Wyeth

storage temp.

2-8°C

SMILES string

Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13

InChI

1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+;

InChI key

JIRISCAPZWLWCG-QPNALZDCSA-N

Biochem/physiol Actions

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Alexandre J C Loucif et al.
British journal of pharmacology, 175(12), 2272-2283 (2017-11-19)
TREK two-pore-domain potassium (K2P ) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other

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