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Merck
CN

C2741

Anti-CCR-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-C-C Chemokine Receptor 1

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD01864142
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
1

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human skeletal muscle, myocytes

UniProt accession no.

P32246

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CCR1(1230)
mouse ... Ccr1(12768)
rat ... Ccr1(57301)

Immunogen

synthetic peptide corresponding to the third extracellular loop of human C-C chemokine receptor 1 (CCR-1), conjugated to KLH. The immunizing peptide has 80% homology with the rat gene and 85% homology with the mouse gene.

Biochem/physiol Actions

CCR1 is a seven transmembrane protein that binds to macrophage inflammatory protein 1 alpha (MIP-1 alpha), monocyte chemoattractant protein 3 (MCP-3) and myeloid progenitor inhibitory factor-1 (MPIF-1). It has important role in protecting the host from inflammatory responses, viruses and parasites.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
084K0939

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J Hesselgesser et al.
The Journal of biological chemistry, 273(25), 15687-15692 (1998-06-23)
The CC chemokines macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES (regulated on activation normal T cell expressed) have been implicated in rheumatoid arthritis and multiple sclerosis. Since their effects are mediated through the CCR1 chemokine receptor, we set up a small

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