C2854
Caspase 2 human
≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein
Synonym(s):
Ich-1, Nedd2
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About This Item
UNSPSC Code:
12352200
MDL number:
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
buffered aqueous solution
specific activity
>1000 units/mg protein
mol wt
inactive proenzyme 56 kDa (active form consists of 17 kDa and 10 kDa subunits), ≥30 kDa
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CASP2(835)
Biochem/physiol Actions
Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.
Caspase 2 plays a major role in both positive and negative regulation of programmed cell death; exists as two spliced variants, Ich-1L (long) and Ich-1S (short).
Physical form
Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin
Other Notes
One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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L Wang et al.
Cell, 78(5), 739-750 (1994-09-09)
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the mammalian homolog of ced-3, interleukin-1 beta-converting enzyme (ICE). Alternative splicing results in two distinct Ich-1 mRNA species. One
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