C2917
Corticotropin Releasing Factor Antagonist
≥97% (HPLC)
Synonym(s):
α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C166H274N46O53S2
CAS Number:
Molecular Weight:
3826.36
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
Gene Information
human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)
Looking for similar products? Visit Product Comparison Guide
Biochem/physiol Actions
Exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors.
The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
S Y Cheng et al.
Neuroscience, 169(1), 236-245 (2010-04-27)
This study was focused on determining the possible role of corticotropin-releasing hormone (CRH) on play fighting in juvenile golden hamsters. As no specific neural sites have been proposed, we looked for changes in CRH innervations at the peak of play-fighting
Ricardo Borges Machado et al.
International journal of endocrinology, 2010, 326151-326151 (2010-07-16)
Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of the
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service