C3042
Corticotropin Releasing Factor human, rat
≥95% (HPLC), powder
Synonym(s):
CRF, CRH
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About This Item
Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
Molecular Weight:
4757.45
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Quality Level
biological source
human, rat
assay
≥95% (HPLC)
form
powder
mol wt
4757.45
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1.00-1.04 mg/mL, colorless
UniProt accession no.
storage temp.
−20°C
InChI key
VXFVFWFSJFSXHN-FAUHKOHMSA-N
Gene Information
human ... CRH(1392)
General description
The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.
Research area: Neuroscience
Research area: Neuroscience
Application
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus
Biochem/physiol Actions
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
监管及禁止进口产品
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Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Salt appetite
Vitamins & Hormones (2017)
Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone
Thome UH, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(2), L376-L385 (2003)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C3042-.1MG | 04061833485231 |
| C3042-.5MG | 04061832676371 |
| C3042-250UG | 04061832676388 |
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