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C3042

Corticotropin Releasing Factor human, rat

Name: Corticotropin Releasing Factor human, rat
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

CRF, CRH

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About This Item

Empirical Formula (Hill Notation):

C₂₀₈H₃₄₄N₆₀O₆₃S₂

CAS Number:

86784-80-7

Molecular Weight:

4757.45

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00213806

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Properties

Quality Segment

200

biological source

human, rat

assay

≥95% (HPLC)

form

powder

mol wt

4757.45

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, colorless

UniProt accession no.

P06850

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

Description

General description

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:

as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Biochem/physiol Actions

Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c