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Merck
CN

C3366

Anti-CXCR5 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CXC Chemokine Receptor 5

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD02096162
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human lymph node, B-cell lymphoma

UniProt accession no.

P32302

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CXCR5(643)
mouse ... Cxcr5(12145)
rat ... Cxcr5(29363)

Immunogen

synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 5 (CXCR5), conjugated to KLH. The immunizing peptide has 94% homology with the rat gene and 100% homology with the mouse gene.

Biochem/physiol Actions

CXCR5 is a multi-pass membrane protein expressed in mature B cells. It binds to B-lymphocyte chemoattractant and regulates the migration of B cells. The expression of CXCR5 is important for CD4 T cell-mediated humoral immune responses.

Physical form

Solution in PBS, 0.1% Sodium Azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL9634
SLBC0558
089K1287
059K1571
084K0799

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Through the looking glass: the diverse in vivo activities of chemokines.
S L Kunkel
The Journal of clinical investigation, 104(10), 1333-1334 (1999-11-24)
Nina Chevalier et al.
Journal of immunology (Baltimore, Md. : 1950), 186(10), 5556-5568 (2011-04-08)
High expression of CXCR5 is one of the defining hallmarks of T follicular helper cells (T(FH)), a CD4 Th cell subset that promotes germinal center reactions and the selection and affinity maturation of B cells. CXCR5 is also expressed on

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