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C3635

4-Chloro-DL-phenylalanine methyl ester hydrochloride

Tryptophan hydroxylase inhibitor, powder

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About This Item

Linear Formula:
ClC6H4CH2CH(NH2)CO2CH3·HCl
CAS Number:
14173-40-1
Molecular Weight:
250.12
NACRES:
NA.32
PubChem Substance ID:
24278310
UNSPSC Code:
12352209
EC Number:
238-024-0
MDL number:
MFCD00012530
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Product Name

4-Chloro-DL-phenylalanine methyl ester hydrochloride,

form

powder

Quality Segment

200

mp

186-189 °C (lit.)

storage temp.

−20°C

SMILES string

Cl.COC(=O)C(N)Cc1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H

InChI key

GCBCWTWQAFLKJG-UHFFFAOYSA-N

Gene Information

human ... TPH1(7166), TPH2(121278)

General description

4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents.

Application

4-Chloro-DL-phenylalanine methyl ester hydrochloride has been used to induce 5-hydroxytryptamine (5-HT) depletion in rats.

Biochem/physiol Actions

Tryptophan hydroxylase inhibitor.
Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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