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C3743

CI 976

Name: CI 976
Brand: SIGMA

>98% (HPLC), solid

Synonym(s):

2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₉NO₄

CAS Number:

114289-47-3

Molecular Weight:

393.56

NACRES:

NA.77

PubChem Substance ID:

329775044

UNSPSC Code:

51111800

MDL number:

MFCD00869662

Assay:

>98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

>98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble <2 mg/mL

storage temp.

2-8°C

SMILES string

CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC

InChI

1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)

InChI key

WAFNZAURAWBNDZ-UHFFFAOYSA-N

Description

Application

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

Biochem/physiol Actions

CI-976 is a potent and specific inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase (ACAT) in vitro.

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

hcodes

H413

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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