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C4292

Cefoperazone sodium salt

Name: Cefoperazone sodium salt
Brand: SIGMA

870 - 1015 μg/mg anhydrous basis

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₆N₉NaO₈S₂

CAS Number:

62893-20-3

Molecular Weight:

667.65

UNSPSC Code:

51102829

NACRES:

NA.85

PubChem Substance ID:

24892686

EC Number:

263-751-5

Beilstein/REAXYS Number:

4902135

MDL number:

MFCD07793331

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Quality Level

200

assay

870-1015 μg/mg (anhydrous basis)

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c5ccc(O)cc5)C(=O)C1=O

InChI

1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1

InChI key

NCFTXMQPRQZFMZ-WERGMSTESA-M

Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

General description

Chemical structure: β-lactam

Application

Cefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.

Biochem/physiol Actions

Cefoperazone exerts its bactericidal effect by inhibiting the mucopeptide synthesis that affects the structure of bacterial cell wall. It has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P280 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000528463

0000478144

0000474249

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A model of cefoperazone tissue penetration: diffusion coefficient and protein binding.

A Meulemans

Antimicrobial agents and chemotherapy, 36(2), 295-298 (1992-02-01)

The apparent diffusion coefficient of a bound drug, cefoperazone, was studied. The protein binding of cefoperazone was studied by voltammetry, a technique which permitted instant measurements. The apparent diffusion coefficients were similar in agar and fibrin and lower in rat

Pharmacokinetics of cefoperazone in the parturient.

B Gonik et al.

Antimicrobial agents and chemotherapy, 30(6), 874-876 (1986-12-01)

Limited pharmacokinetic data for cefoperazone are available from the parturient. Because cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney, pregnancy-induced physiologic alterations can influence its deposition and clearance. Twelve term parturients receiving

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning.

Christopher Staley et al.

Microbiome, 5(1), 87-87 (2017-08-02)

Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the recipient intestine, which

Evaluation of four protocols for the detection and isolation of thermophilic Campylobacter from different matrices.

M Ugarte-Ruiz et al.

Journal of applied microbiology, 113(1), 200-208 (2012-04-27)

To identify the optimal method for detection of thermophilic Campylobacter at various stages in the food chain, three culture-dependent (direct plating, Bolton and Preston enrichment) and one molecular method (qPCR) were compared for three matrices: poultry faeces (n = 38), neck skin

Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis.

Katie L Mason et al.

Infection and immunity, 80(1), 150-158 (2011-10-12)

The indigenous bacterial microbiome of the stomach, including lactobacilli, is vital in promoting colonization resistance against Candida albicans. However, there are gaps in our understanding about C. albicans gastric colonization versus disease, especially during the postantibiotic recovery phase. This study

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Global Trade Item Number

SKU	GTIN
C4292-1G	04061833491973
C4292-5G	04061833491980

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