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C4369

Calcipotriol hydrate

Name: Calcipotriol hydrate
Brand: SIGMA

≥98% (HPLC), powder, Vitamin D3 analog

Synonym(s):

(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol, Calcipotriene

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₄₀O₃ · xH₂O

CAS Number:

112965-21-6

Molecular Weight:

412.60 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329775060

NACRES:

NA.77

MDL number:

MFCD10567086

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Calcipotriol hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 15 mg/mL, clear

storage temp.

room temp

SMILES string

O.C[C@H](\C=C\[C@@H](O)C1CC1)C2CCC3\C(CCC[C@]23C)=C\C=C4\C[C@@H](O)C[C@H](O)C4=C

InChI

1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1

InChI key

XBKHACNRWFKJNC-MANNPBRJSA-N

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Calcipotriol is a synthetic derivative of calcitriol, or Vitamin D.

Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H310,H317,H319,H361fd,H372

pcodes

P202 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1B - STOT RE 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000527045

0000527038

0000474860

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Effects of vitamin D3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells.

Zaidoon Al-Jaderi et al.

Toxins, 5(11), 1932-1947 (2013-10-31)

We describe here the effects of three drugs that are either approved or have the potential for treating multiple sclerosis (MS) patients through the in vitro activities of human natural killer (NK) cells and dendritic cells (DCs). Our results indicate

Topical vitamin D₃ analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions.

E Sato-Deguchi et al.

The British journal of dermatology, 167(1), 77-84 (2012-03-06)

Psoriasis is a chronic inflammatory skin disease of unknown aetiology, and an active form of vitamin D(3) (1α,25-dihydroxyvitamin D(3)) and its analogues (VD3As) are widely used topical reagents for psoriasis treatment. Besides their well-known calcium homeostasis functions, VD3As have been

Preliminary study of the efficacy and tolerability of combination therapy with calcipotriene ointment 0.005% and tacrolimus ointment 0.1% in the treatment of stable plaque psoriasis.

Andrés Tirado-Sánchez et al.

Cutis, 90(3), 140-144 (2012-10-26)

Calcipotriene ointment is widely used in the topical treatment of psoriasis, with tacrolimus ointment as an effective alternative in controlling stable plaque psoriasis. The efficacy of the combination of both products on stable plaque psoriasis has not been assessed in

Comparison of the antipsoriatic effect and tolerability of calcipotriol-containing products in the treatment of psoriasis vulgaris using a modified psoriasis plaque test.

Catherine Queille-Roussel et al.

Clinical drug investigation, 32(9), 613-619 (2012-08-01)

In 1972, Dumas and Scholtz developed the psoriasis plaque test to evaluate the potency of local corticosteroids. Through further modification of this method, the efficacy between antipsoriatic products can be differentiated. This method allowed for the simultaneous application of several

Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin α₂β₁ receptor.

Nina Ø Knudsen et al.

International journal of pharmaceutics, 428(1-2), 171-177 (2012-03-15)

Peptide conjugation to the surface of stealth liposomes has been studied for liposomal drug targeting to cells expressing specific receptors to provide a site-specific drug delivery. This study investigated the potential of peptide-conjugated liposomes for targeting cells expressing the human

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Global Trade Item Number

SKU	GTIN
C4369-10MG	04061833492024
C4369-50MG	04061833217993

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