C4483
CD152/Fc Chimera, Cytolytic from mouse
recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonym(s):
CTLA4/Fc Chimera, cytolytic
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About This Item
Form:
buffered aqueous solution
Assay:
≥99% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in NS.1 cells
Mol wt:
97 kDa
biological source
mouse
Quality Segment
recombinant
expressed in NS.1 cells
assay
≥99% (SDS-PAGE)
form
buffered aqueous solution
mol wt
97 kDa
packaging
pkg of 1 mg
storage condition
avoid repeated freeze/thaw cycles
impurities
≤1 EU/mg protein Endotoxin level (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Cd152(12477), Ctla4(12477)
General description
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Biochem/physiol Actions
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
Physical form
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
Preparation Note
Purified from serum-free tissue culture supernatant
Other Notes
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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