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C4542

Cyclobenzaprine hydrochloride

Name: Cyclobenzaprine hydrochloride
Brand: SIGMA

Synonym(s):

5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁N · HCl

CAS Number:

6202-23-9

Molecular Weight:

311.85

NACRES:

NA.77

PubChem Substance ID:

24278315

UNSPSC Code:

12352200

EC Number:

228-264-4

MDL number:

MFCD00079039

Form:

powder

Quality level:

200

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form

powder

Quality Level

200

originator

Johnson & Johnson

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

InChI key

VXEAYBOGHINOKW-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

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General description

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of noradrenaline. It is used to treat neck, back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

Application

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.

Cyclobenzaprine hydrochloride has been used to study its effects on the muscles of dystrophin-deficient mdx5Cv mice.

Biochem/physiol Actions

Cyclobenzaprine hydrochloride is a type of tricyclic skeletal drug, which is commonly used as a muscle relaxant. It is very effective in treating intractable pain of cervical and lumbar origin caused by skeletal muscle spasm. cyclobenzaprine hydrochloride inhibit tonic α-mononeuronal excitation mediated by descending serotonergic systems by interacting with serotonin receptors at the spinal cord level.

Skeletal muscle relaxant; 5-HT₂ serotonin receptor antagonist.

Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H312 + H332

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Determination of degradation products of Cyclobenzaprine hydrochloride, Lidocaine and Piroxicam in a semi-topical formulation: MS-MS confirmation of unknown impurities

Cioroiu BI, et al.

Journal of Chromatographic Science, 54(6), 902-911 (2016)

Cyclobenzaprine in intractable pain syndromes with muscle spasm

Brown BR and Womble J

JAMA : The Journal of the American Medical Association, 240(11), 1151-1152 (1978)

Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems.

H Kobayashi et al.

European journal of pharmacology, 311(1), 29-35 (1996-09-05)

The centrally acting muscle relaxant cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. In the present study, we examined the effects of cyclobenzaprine on descending neurons by

Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials

Borenstein DG and Korn S

Clinical Therapeutics, 25(4), 1056-1073 (2003)

Psychiatric Side Effects of Prescription and Over-the-counter Medications: Recognition and Management (1998)

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Global Trade Item Number

SKU	GTIN
C4542-1G	04061833492314
C4542-5G	04061832089836

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