C4615
Cloricromene
≥98% (HPLC), solid
Synonym(s):
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6
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About This Item
Empirical Formula (Hill Notation):
C20H26ClNO5 · HCl
CAS Number:
Molecular Weight:
432.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
CCCZJRFQJNGCCU-UHFFFAOYSA-N
SMILES string
Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl
InChI
1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
assay
≥98% (HPLC)
form
solid
color
white
mp
221-222.3 °C
solubility
DMSO: 17 mg/mL, H2O: insoluble
storage temp.
2-8°C
Biochem/physiol Actions
Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation.
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D Altavilla et al.
The American journal of physiology, 268(4 Pt 2), H1412-H1417 (1995-04-01)
Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase
G Calapai et al.
Naunyn-Schmiedeberg's archives of pharmacology, 351(2), 209-215 (1995-02-01)
The effects of different doses (0.25, 0.5, 1 and 2 mg/kg i.p.) of cloricromene, a coumarine derivative, have been investigated on brain malondialdehyde levels, brain edema, myeloperoxidase activity, survival, locomotor hyperactivity and hippocampal neuronal loss following transient cerebral ischemia induced
Carmelo Muià et al.
Naunyn-Schmiedeberg's archives of pharmacology, 373(1), 51-59 (2006-03-31)
Recent studies have demonstrated that cloricromene, a coumarin derivative, exerts protective effects in models of inflammation and shock. Tumour necrosis factor plays a pivotal role in the induction of genes involved in physiological processes, as well as in the response
Rosario Pignatello et al.
AAPS PharmSciTech, 7(1), E27-E27 (2006-04-06)
The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle suspensions were made using inert polymer resins (Eudragit RS100 and
Ornella Francioso et al.
Langmuir : the ACS journal of surfaces and colloids, 35(13), 4518-4526 (2019-02-15)
The adsorption of humic substances on Ag nanoparticles (AgNPs) is of crucial environmental importance and determines the toxicity of these NPs and the structure of adsorbed organic matter. In this work, the adsorption of two standard soil and leonardite International Humic
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