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C4615

Cloricromene

Name: Cloricromene
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₆ClNO₅ · HCl

CAS Number:

74697-28-2

Molecular Weight:

432.34

NACRES:

NA.77

PubChem Substance ID:

24892703

UNSPSC Code:

12352200

MDL number:

MFCD06409251

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

white

mp

221-222.3 °C

solubility

DMSO: 17 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl

InChI

1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H

InChI key

CCCZJRFQJNGCCU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA₂activation.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

064K4620

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Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.

R Pignatello et al.

The Journal of pharmacy and pharmacology, 58(7), 1001-1005 (2006-06-30)

The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but

Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium.

L Groban et al.

Clinical and experimental pharmacology & physiology, 25(6), 417-423 (1998-07-23)

1. The aim of the present investigation was to evaluate the effect of cloricromene on myocardial infarct size, regional myocardial blood flow and neutrophil accumulation in a canine model of ischaemia-reperfusion. 2. Dogs were instrumented to measure blood pressure, left

Retinal and systemic pharmacokinetics of the anti-inflammatory drug cloricromene following oral administration in the rat and rabbit.

Claudio Bucolo et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 23(3), 257-263 (2007-06-27)

The aim of this study was to evaluate the retina and plasma distribution of cloricromene, a coumarin derivative, and its active metabolite (MET) after an oral administration in rabbits and rats. A single dose of cloricromene was orally administered to

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Global Trade Item Number

SKU	GTIN
C4615-25MG	04061833269879
C4615-5MG	04061833269886