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C4654

Sigma-Aldrich

Cytidine

BioReagent, suitable for cell culture, powder, ≥99%

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Synonym(s):
Cytosine β-D-riboside, Cytosine-1-β-D-ribofuranoside
Empirical Formula (Hill Notation):
C9H13N3O5
CAS Number:
65-46-3
Molecular Weight:
243.22
Beilstein:
89173
EC Number:
200-610-9
MDL number:
MFCD00006545
PubChem Substance ID:
24892710
NACRES:
NA.75

biological source

synthetic

Quality Level

200

product line

BioReagent

Assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

210-220 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1

InChI key

UHDGCWIWMRVCDJ-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

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General description

Cytidine is a nucleoside molecule. It is formed when cytosine is attached to a ribose ring through a β-N1-glycosidic bond.

Application

Cytidine has been used as a component to prepare ribonucleoside stock solution to assess its effects on the anaerobic growth of several Bacillus mojavensis strains.
Cytidine has been used as a non-essential aminoacid component of minimal essential medium (MEM) to analyse interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts. It has also been used as a supplement in the culture medium of HeLa cells, to study the effects of cytidine addition on rods and rings (RR) induced by glutamine deprivation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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  6. How do I dissolve Product No. C4654, Cytidine?

    The product is tested for solubility in water at 50 mg/mL.  It may be soluble at higher concentrations as well.  Solutions of cytidine are clear or can be faint yellow in color.

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Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA and trigger chromatin opening for recruitment of other non-pioneer transcription factors. However, critical properties of PTFs are still poorly understood, such as how these transcription factors selectively recognize
G P Gerrits et al.
Clinical chemistry, 34(7), 1439-1442 (1988-07-01)
Disturbances in the metabolism of purines and pyrimidines in neurologically affected patients can be reflected by aberrant concentrations of nucleosides and nucleobases in cerebrospinal fluid (CSF). However, normal values, especially for children at different ages, are lacking. We collected 1000
Koji Hayakawa et al.
The Journal of biological chemistry, 288(24), 17099-17110 (2013-04-30)
The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology. Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene. To
Leonidas Chouliaras et al.
Neurobiology of aging, 34(9), 2091-2099 (2013-04-16)
Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain.
Yubing Liu et al.
eLife, 7 (2018-08-14)
Ribosome degradation through the autophagy-lysosome pathway is crucial for cell survival during nutrient starvation, but whether it occurs under normal growth conditions and contributes to animal physiology remains unaddressed. In this study, we identified RNST-2, a C. elegans T2 family
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