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C4780

Coenzyme A sodium salt hydrate

Name: Coenzyme A sodium salt hydrate
Brand: SIGMA

BioReagent, suitable for cell culture

Synonym(s):

CoA Na₂

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O

CAS Number:

55672-92-9

Molecular Weight:

767.53 (anhydrous free acid basis)

MDL number:

MFCD00079020

UNSPSC Code:

12352205

PubChem Substance ID:

24892723

EC Number:

259-747-8

NACRES:

NA.75

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biological source

yeast

Quality Level

200

description

cofactor for acyl transfer

product line

BioReagent

assay

≥85% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS

InChI

1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H

InChI key

SYTRWOCXZXQBPW-CLVRNSBASA-M

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Application

Coenzyme A sodium salt hydrate has been used:

in the branch chain aminotransferase enzymatic assay and protein determination
in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Biochem/physiol Actions

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

Analysis Note

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000327392

0000420099

0000420113

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Nonalcoholic fatty liver disease and mitochondrial dysfunction.

Yongzhong Wei et al.

World journal of gastroenterology, 14(2), 193-199 (2008-01-12)

Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.

Balaji Srinivasan et al.

Nature chemical biology, 11(10), 784-792 (2015-09-01)

The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.

Yao Rong et al.

eLife, 10 (2021-08-20)

TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression

Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria.

Krista Yang et al.

STAR protocols, 2(3), 100687-100687 (2021-08-18)

Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation.

Le Tran Phuc Khoa et al.

Cell stem cell, 27(3), 441-458 (2020-07-02)

Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process

Global Trade Item Number

SKU	GTIN
C4780-100MG	04061833492772
C4780-10MG	04061833492864
C4780-25MG	04061833492871

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