C4992
Carboxyatractyloside potassium salt
≥98% (HPLC), from Xanthium sibiricum, solid
Synonym(s):
C-ATR, CAT
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About This Item
Empirical Formula (Hill Notation):
C31H46O18S2 · xK+
CAS Number:
Molecular Weight:
770.82 (free acid basis)
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
biological source
Xanthium sibiricum
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D -34 to -48°, c = 0.5 in water
storage condition
desiccated
color
white
solubility
H2O: ≥10 mg/mL
storage temp.
−20°C
Application
Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells.
Biochem/physiol Actions
Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis.
Features and Benefits
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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