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Merck
CN

C5020

Cefazolin sodium salt

89.1-110.1%

Synonym(s):

Cefazoline sodium, Monosodium cefazolin

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About This Item

Empirical Formula (Hill Notation):
C14H13N8NaO4S3
CAS Number:
27164-46-1
Molecular Weight:
476.49
UNSPSC Code:
51282532
NACRES:
NA.76
PubChem Substance ID:
24278318
EC Number:
248-278-4
Beilstein/REAXYS Number:
3585038
MDL number:
MFCD00056883

Key Documents

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Product Name

Cefazolin sodium salt, 89.1-110.1%

InChI key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

InChI

1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

SMILES string

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C([O-])=O)s1

assay

89.1-110.1%

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Related Categories

Biochem/physiol Actions

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins, especially PBP2 and PBP4 on bacterial cell wall mucopeptide synthesis.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Preparation Note

Freely soluble in water, very slightly soluble in chloroform and ethanol.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000492391
0000492391
0000467632
0000467631
0000467632

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Therapeutic drug monitoring, 40(6), 682-692 (2018-07-18)
Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, and reliable analytical method for monitoring the concentrations in plasma, including unbound concentrations for highly protein-bound drugs. The aim of the current work was to develop and validate
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