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Merck
CN

C5020

Cefazolin sodium salt

89.1-110.1%

Synonym(s):

Cefazoline sodium, Monosodium cefazolin

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About This Item

Empirical Formula (Hill Notation):
C14H13N8NaO4S3
CAS Number:
27164-46-1
Molecular Weight:
476.49
UNSPSC Code:
51282532
NACRES:
NA.76
PubChem Substance ID:
24278318
EC Number:
248-278-4
Beilstein/REAXYS Number:
3585038
MDL number:
MFCD00056883

Key Documents

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InChI key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

InChI

1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

SMILES string

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C([O-])=O)s1

assay

89.1-110.1%

form

powder

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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General description

Chemical structure: β-lactam

Biochem/physiol Actions

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins, especially PBP2 and PBP4 on bacterial cell wall mucopeptide synthesis.

Preparation Note

Freely soluble in water, very slightly soluble in chloroform and ethanol.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000519634
0000519634
0000521827
0000521827
0000492391

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Kevin E Chan et al.
Journal of the American Society of Nephrology : JASN, 23(9), 1551-1559 (2012-08-21)
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Keita Kamikura et al.
Journal of materials science. Materials in medicine, 28(9), 132-132 (2017-07-27)
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Jabeen Noore et al.
Antimicrobial agents and chemotherapy, 57(3), 1283-1290 (2013-01-01)
The increasing resistance of bacteria to conventional antibiotics and the challenges posed by intracellular bacteria, which may be responsible for chronic and recurrent infections, have driven the need for advanced antimicrobial drugs for effective elimination of both extra- and intracellular
Colleen K Cagno et al.
American family physician, 86(1), 59-65 (2012-09-12)
Group B streptococcus is the leading cause of early-onset neonatal sepsis in the United States. Universal screening is recommended for pregnant women at 35 to 37 weeks' gestation. The Centers for Disease Control and Prevention recently updated its guideline for
Martin Andreas et al.
The Annals of thoracic surgery, 95(4), 1323-1329 (2013-03-07)
Internal mammary artery (IMA) harvesting for coronary artery bypass grafting (CABG) influences tissue perfusion and represents a risk factor for deep sternal wound infection (DSWI). Cephalosporins are routinely administered for prophylaxis during cardiac operations to decrease perioperative wound infections. We
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