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C5624

Cryptotanshinone

≥98% (HPLC)

Synonym(s):

1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione, Cryptotanshinon, Tanshinone c

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About This Item

Empirical Formula (Hill Notation):
C19H20O3
CAS Number:
35825-57-1
Molecular Weight:
296.36
NACRES:
NA.77
PubChem Substance ID:
329775097
UNSPSC Code:
12352200
MDL number:
MFCD07636810
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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -80 to -99°, c = 0.5 in chloroform-d

storage condition

desiccated, protect from light

color

orange-brown

solubility

DMSO: ≥5 mg/mL

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23

InChI

1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1

InChI key

GVKKJJOMQCNPGB-JTQLQIEISA-N

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Biochem/physiol Actions

Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.
Cryptotanshinone is a specific STAT3 inhibitor. It prevents STAT3 dimerization.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000220173
0000220174
0000215880
0000220173
0000220174

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Jia-Hau Yen et al.
Molecular therapy oncolytics, 26, 158-174 (2022-07-22)
Dampening tumor growth by converting tumor-associated macrophages (TAMs) from M2/repair-types to M1/kill-types is of high interest. Here, we show that cryptotanshinone (CPT) can function as an antitumor immune modulator that switches TAMs from an M2 to an M1 phenotype, leading
Zhiyuan Lu et al.
Molecular biology reports, 51(1), 436-436 (2024-03-23)
Elevated levels of adipokine chemerin have been identified in oral squamous cell carcinoma (OSCC) and found to be associated with metastasis to the cervical lymph nodes. The underlying mechanism through which chemerin affects OSCC progression is unclear. The aims of
Yongpeng Zhang et al.
Drug development research, 82(4), 581-588 (2020-12-20)
Coronary microembolization (CME) is a prevalent cardiovascular disease, especially nowadays when percutaneous coronary intervention is widely applied. However, neither cardio-protective agents nor devices for distal protection could effectively prevent the occurrence of CME. Therefore, we aimed to develop a new
Hang Yu et al.
Archives of pharmacal research, 35(8), 1457-1464 (2012-09-04)
Cryptotanshinone, tanshinone I and tanshinone IIA are three major components in the extract of Salvia miltiorrhiza with pharmacological significance. However, their effective utilization is limited due to poor water solubility and bioavailability. Solid dispersion (SD) of the extract of Salvia
Xiao-Bing Li et al.
Molecules (Basel, Switzerland), 17(3), 2388-2407 (2012-03-01)
Drying is the most common and fundamental procedure in the post-harvest processing which contributes to the quality and valuation of medicinal plants. However, attention to and research work on this aspect is relatively poor. In this paper, we reveal dynamic
View All Related Papers

Global Trade Item Number

SKUGTIN
C5624-5MG04061832631837
C5624-25MG04061832631820

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