C5738
Anti-Calcium Channel (β2 subunit) (Voltage Gated Ca2+ Channel) antibody produced in rabbit
~1 mg/mL, fractionated antiserum, buffered aqueous solution
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
fractionated antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
western blot: 5-10 μg/mL using brain tissues lysate
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CACNB2(783)
mouse ... Cacnb2(12296)
rat ... Cacnb2(116600)
General description
CACNB2 (Voltage-dependent L-type calcium channel subunit β-2) is particularly expressed in cardiovascular tissue.
Immunogen
synthetic peptide derived from the rat β2 calcium channel subunit conjugated to KLH.
Application
Anti-Calcium Channel (β2 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using rat brain tissue lysate.
Biochem/physiol Actions
CACNB2 (Voltage-dependent L-type calcium channel subunit β-2) is a subunit of voltage-activated L-type calcium channelsl. CACNB2 regulates voltage-dependent calcium currents through direct interaction with α1 subunits. Loss of function mutation in CACNB2 is associated with familial cardiac death combined with short QT intervals and ST-segment elevation. It is down-regulated in humans with atrial fibrillation and miR-21 is suggested to be responsible for the down-regulation. Mutations in CACNB2 are linked to autism spectrum disorders.
Specifically recognizes a splice variant of β2 (68 kDa) from human, mouse and rat.
Physical form
Solution in phosphate buffered saline containing 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
Try our Product Selector Tool to narrow your options
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.