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Merck
CN

C5762

Colominic acid sodium salt from Escherichia coli

Synonym(s):

Poly[2,8-(N-acetylneuraminic acid sodium salt)]

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About This Item

Linear Formula:
(C11H16NNaO8)n
CAS Number:
70431-34-4
NACRES:
NA.76
UNSPSC Code:
51102829
MDL number:
MFCD00133197

Key Documents

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InChI

1S/C11H20NO7.3Na/c1-6(15)12-10-7(16)4-9(18-3-2-13)19-11(10)8(17)5-14;;;/h3,7-11,13-14,16-17H,2,4-5H2,1H3,(H,12,15);;;/q;3*+1

InChI key

IPYNPWIUCZLARC-UHFFFAOYSA-N

form

powder

solubility

H2O: 50 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

Quality Level

200

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Application

Colominic acid is used to study protein polysialylation processes. It is a substrate for CMP-NeuAc:(NeuAcα2→8)n (colominic acid) sialyltransferase.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCF1004
SLBX1715
SLBT1171
SLBS8176
SLBS1909V

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J Roth et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(9), 2999-3003 (1988-05-01)
A unique structural feature of the neural cell adhesion molecule N-CAM is the presence of homopolymers of alpha (2----8)-linked sialic acid units. We have used two specific probes for the detection of poly(sialic acid) in normal human kidney and Wilms
J Roth et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(7), 1969-1973 (1987-04-01)
We report the presence of alpha(2----8)-linked polysialic acid as detected with a monoclonal antibody outside the nervous tissue in the postnatal developing rat kidney. By immunoblot analysis, the reactivity was confined to a broad band of apparent molecular mass 200-250
J Finne et al.
Journal of immunology (Baltimore, Md. : 1950), 138(12), 4402-4407 (1987-06-15)
The structurally similar polysialic acid capsules of group B meningococci and Escherichia coli K1 are poor immunogens, and attempts are currently being made to improve their immunogenicity by chemical modifications. An IgG monoclonal antibody to these polysialic acid capsules was
Nina Westphal et al.
Scientific reports, 7(1), 13631-13631 (2017-10-21)
The neural cell adhesion molecule (NCAM) is the major carrier of polysialic acid (PSA) which modulates NCAM functions of neural cells at the cell surface. In previous studies, we have shown that stimulation of cultured neurons with surrogate NCAM ligands

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