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Merck
CN

C5808

Cortistatin-14

≥97% (HPLC)

Synonym(s):

CST-14, Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

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About This Item

Empirical Formula (Hill Notation):
C81H113N19O19S2
CAS Number:
186901-48-4
Molecular Weight:
1721.01
NACRES:
NA.77
PubChem Substance ID:
329775102
UNSPSC Code:
12352202
MDL number:
MFCD01075120

Key Documents

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Product Name

Cortistatin-14, ≥97% (HPLC)

InChI

1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1

SMILES string

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc6ccccc6)NC1=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H]7CCCN7

InChI key

DDRPLNQJNRBRNY-WYYADCIBSA-N

assay

≥97% (HPLC)

form

powder

mol wt

~_1.7 kDa

packaging

vial of 0.5 mg

solubility

1% acetic acid: 1 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Application

Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).

Biochem/physiol Actions

Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.
Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.

General description

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. In the peripheral system, it is produced in adrenal, thyroid, parathyroid, stomach, intestine, pancreas, testes, liver and kidney.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000366416
0000356330
0000342220
0000313481
0000341582

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A cortical neuropeptide with neuronal depressant and sleep-modulating properties
de Lecea L, et al.
Nature, 381(6579), 242-242 (1996)
Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems
Markovics A, et al.
Journal of Molecular Neuroscience, 46(1), 40-50 (2012)
Cortistatin and pituitary hormone secretion in rat
Baranowska B, et al.
Acta Physiologica Polonica, 60(1), 151-151 (2009)
J R Criado et al.
Journal of neuroscience research, 56(6), 611-619 (1999-06-22)
Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal function are different from those of somatostatin. We studied the structural basis for
Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain
Braun H, et al.
Brain Research, 803(1-2), 54-60 (1998)
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