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C5851

CGP 35348 hydrate

Name: CGP 35348 hydrate
Brand: SIGMA

≥97% (NMR), solid

Synonym(s):

(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

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About This Item

Empirical Formula (Hill Notation):

C₈H₂₀NO₄P · xH₂O

CAS Number:

123690-79-9

Molecular Weight:

225.22 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329775103

UNSPSC Code:

12352200

MDL number:

MFCD11045877

Assay:

≥97% (NMR)

Form:

solid

Storage condition:

desiccated

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Properties

Quality Segment

100

assay

≥97% (NMR)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: >20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.CCOC(OCC)P(O)(=O)CCCN

InChI

1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2

InChI key

SRBHGEXMDCJOMS-UHFFFAOYSA-N

Description

Application

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

to study its effects on intrinsic optical signal (IOS) in rat hippocampus
alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
to study its effects on hepatocellular carcinoma cells (HCC)

Biochem/physiol Actions

CGP 35348 is a γ-aminobutyric acid-B (GABA_B) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Product is hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c