Anti-Calcium Channel (β₄ Subunit) (Voltage Gated Ca²⁺ Channel) antibody produced in rabbit

The gene CACNB4 (Calcium channel voltage-dependent subunit beta 4) is mapped to human chromosome 2q22-23. It is present at the membrane as well as the nucleus.

synthetic peptide derived from the rat β₄ calcium channel subunit conjugated to KLH.

Anti-Calcium Channel (β-4 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using brain tissue lysate.
The antibody has been used for:

• western blotting of proteins extracted from different brain regions of the mouse
• western blotting of proteins isolated from primary culture of mouse cerebral cortical neurons

Specifically recognizes a splice variant of β₄ (55 kDa).

The CACNB4 (Calcium channel voltage-dependent subunit β 4) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. Mutations in CACNB4 are associated with idiopathic generalized epilepsy and episodic ataxia. CACNB4 interacts with heterochromatin protein 1γ (HP1γ). The interaction attenuates the gene silencing activity by HP1.

Solution in phosphate buffered saline containing 0.08% sodium azide.

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