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C6239

Cinalukast

~98% (HPLC)

Synonym(s):

(E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid, Ro 24-5913

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About This Item

Empirical Formula (Hill Notation):
C23H28N2O3S
CAS Number:
128312-51-6
Molecular Weight:
412.55
NACRES:
NA.77
PubChem Substance ID:
24724447
UNSPSC Code:
12352202
MDL number:
MFCD00864778
Assay:
~98% (HPLC)
Form:
solid
Quality level:
100
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assay

~98% (HPLC)

Quality Level

100

form

solid

color

off-white

solubility

DMSO: >10 mg/mL, H2O: insoluble

originator

Roche

storage temp.

2-8°C

SMILES string

CCC(CC)(CC(=O)Nc1cccc(\C=C\c2nc(cs2)C3CCC3)c1)C(O)=O

InChI

1S/C23H28N2O3S/c1-3-23(4-2,22(27)28)14-20(26)24-18-10-5-7-16(13-18)11-12-21-25-19(15-29-21)17-8-6-9-17/h5,7,10-13,15,17H,3-4,6,8-9,14H2,1-2H3,(H,24,26)(H,27,28)/b12-11+

InChI key

BZMKNPGKXJAIDV-VAWYXSNFSA-N

Gene Information

human ... CYSLTR1(10800)

Biochem/physiol Actions

Specific CysLT1 leukotriene receptor antagonist.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
083K4616

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Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Ro 24-5913: a potent, specific, orally active LTD4 antagonist.
M O'Donnell
Annals of the New York Academy of Sciences, 629, 413-415 (1991-01-01)
Michael Föller et al.
European journal of clinical investigation, 40(6), 534-540 (2010-05-12)
Fever and hyperthermia are frequently associated with anaemia. Under most clinical conditions, they are considered to be two mutually independent clinical consequences of a common cause. The present study explored the possibility that anaemia results from temperature-sensitive suicidal erythrocyte death
H Maehr et al.
Bioorganic & medicinal chemistry, 5(3), 493-496 (1997-03-01)
Structure optimization of the leukotriene D4 antagonist Ro24-5913 was attempted by combinatorial chemistry. Three segments in its N-succinyl-3-(2-thiazolylethenyl)anilide skeleton, designated as A, B, and C coincided with the thiazolyl, aniline, and N-acyl moieties, respectively, and were selected for variations in
View All Related Papers

Global Trade Item Number

SKUGTIN
C6239-5MG04061832785271