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C6492

Ciproxifan hydrochloride

≥98% (HPLC), solid

Synonym(s):

Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H18N2O2 · HCl
CAS Number:
1049741-81-2
Molecular Weight:
306.79
NACRES:
NA.77
PubChem Substance ID:
24724449
UNSPSC Code:
12352200
MDL number:
MFCD08705321
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, under inert gas
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Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, under inert gas

color

off-white

solubility

DMSO: 30 mg/mL, water, high purity: 30 mg/mL

storage temp.

2-8°C

SMILES string

Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2

InChI

1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H

InChI key

PWAPSKMHZQQTRJ-UHFFFAOYSA-N

Biochem/physiol Actions

Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
H3 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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